Skip to content
Navigate to homepage - Cerba Research

Next-Generation Sequencing For Solid Tumors

We can maximize the efficacy of your solid tumor therapy thanks to our expertise in genomics. Learn more about our NGS services for solid tumors.

Genomic Solutions for Your Solid Tumor Project

At Cerba Research, our expert team can optimize solid tumor trials due to our extensive experience in genomics and access to a full range of sophisticated instruments and robust broad panel assays. We are also continuously verifying solid tumor international guidelines and adapting our existing panels accordingly.

Our experienced scientific team provides a flexible and responsive approach to your solid tumor trial. Note that about 50% of our oncology trials are solid tumor driven currently and may require broad panel NGS assays.

Need to assess the total number of somatic mutations? Or determine the alteration of one or multiple nucleotides of your DNA sequence? Thanks to Cerba Research and Cerba Healthcare’s experience and history in genomics, we are able to propose broad panel NGS assays. These may cover the majority of gene alterations with established, emerging, and exploratory value across lung, ovarian, breast, colon, melanoma, bladder, GIST, and rare tumors (sarcomas).

Additionally, those panels may also determine HRD score, TMB status, and MSI. Panels may detect many hallmarks of cancer such as, but not limited to:

  • Single nucleotide variants (SNVs)
  • Insertions-deletions (indels)
  • Copy number variations (CNVs)
  • Gene fusions (translocations)
a computer-generated image of two cancer cells spreading

Customize a New Panel According to Your Trial Needs

Allow your scientific project a sufficient amount of time for analytical validation. If an NGS assay is already in accordance with your trial needs, the turnaround time from receipt of approved samples to result is normally 10-15 days.

Our NGS For Solid Tumors

A full range of capabilities and an Scientific team dedicated to your trial

Next Generation Sequencing

Cerba OncoSign Panel

42 DNA

17 RNA (fusions)

15 microsatellites

Hallmarks of cancer

Cerba OncoSign panel covers mutations with established and emerging value across lung, ovarian, breast, colon, melanoma, bladder, GIST and more. It may also determine MSI-H and may be performed on FFPE (OncoSign) & liquid biopsy (OncoSign ctDNA). It is also performed on FFPE for routine clinical use in Europe.

qPCR

EGFR (FFPE / liquid biopsy)
Endopredict

Digital PCR

BRAF V600E

FISH

Amplifications: MET / HER2
Fusions: ALK / ROS1 / RET / NTRK1-2-3

Microsatellite Instability (MSI)

Microsatellite instability (MSI) status may be provided by using the OncoSign panel.

Molecular Analysis in Non-small Cell Lung Cancer (NSCLC)

With precision medicine becoming a more integral component of NSCLC treatment, molecular testing is an important step to help researchers, pathologists, and oncologists understand the genetic underpinnings of this devastating disease.

Discover how Cerba Research envisions the usage of an NGS-based broad panel assay to detect clinically relevant genetic alterations in NSCLC. Read our article on Precision medicine for NSCLC to find out more.

 

 

 

Learn more
A photo of a scientist in a laboratory using genomic extraction kits

Cerba OncoSign 600+ For Solid Tumors

Benefit from Cerba OncoSign 600+, our extra large NGS panel which may detect 638 DNA-based genes including 20 fusion genes. Cerba OncoSign 600+ panel covers mutations with established, emerging and exploratory value across,lung, ovarian, breast, colon, melanoma, bladder, GIST, rare tumors and more It will also determine MSI & TMB (HRD coming soon).

Microsatellite instability (MSI)

Microsatellite instability (MSI) is a modification that occurs in cancer cells where the number of repeated DNA bases in a microsatellite (a short sequence of DNA) is different from what it was when the microsatellite was inherited. MSI may be caused by DNA mistakes that are not corrected and is found most often in colorectal, cancer, and endometrial cancer. Knowing whether a cancer has high MSI may be a predictive marker for response to checkpoint inhibitor regimens or clinical trial options.

Tumor Mutational Burden (TMB)

Tumor Mutational Burden (TMB) is an approximate measure of the total number of somatic mutations. Theoretically, high TMB levels will correlate with high neoantigen levels that will activate an antitumor immune response. TMB is currently an emerging immune biomarker for patients with metastatic non-small cell lung cancer based on clinical data. For example, tumors that have a high TMB appear to be more likely to respond to certain types of immunotherapy

Fusion gene

A fusion gene is the juxtaposition of two otherwise separate genes, the transcription of which is translated into an abnormal protein (often a fusion protein that leads to a constitutive protein tyrosine kinase) that drives the growth of many cancers. The detection of fusion genes, also known as gene rearrangements, are important in targeted therapy clinical development and a great example of precision medicine. Such fusion genes may be ALK, ROS1 and NTRK1-3 to name a few.

Copy number variants (CNVs)

Copy number variants (CNVs) refer to a circumstance to which the number of copies of a specific segment of DNA varies among different individuals’ genomes. Genetic variants, including insertions, deletions, and duplications of sections of DNA, are collectively referred to as CNVs. CNVs account for a large proportion of genetic variation between individuals and present a unique opportunity to investigate the impact of CNVs in drug development.

Single nucleotide variants (SNVs)

Single nucleotide variants (SNVs) is a DNA sequence variation that occurs when a single nucleotide, such as adenine, thymine, cytosine, or guanine, is altered.  SNVs are sometimes referred to as single nucleotide polymorphisms.

The study of SNVs in clinical trials is relevant in providing  information on disease risk assessment.

Don’t hesitate to contact our scientific team to help you with your solid tumor sequencing needs!

Cerba Paris: Our Comprehensive Oncopanels

Genes Cancer Type Instrument TAT* Bone marrow ctDNA FFPE

Cerba OncoSign

59

Solid tumors (important hallmarks of cancer)

42 DNA

17 RNA (fusions)

15 microsatellites

HRD status (CE-IVD marked & in a separate panel)

NextSeq

15

X

X

Cerba OncoSign 600+

658

Solid tumors (important hallmarks of cancer)

638 DNA

20 RNA (fusions)

TMB, MSI, HRD

NextSeq

15

X

Genes

59

Cancer Type

Solid tumors (important hallmarks of cancer)

42 DNA

17 RNA (fusions)

15 microsatellites

HRD status (CE-IVD marked & in a separate panel)

Instrument

NextSeq

TAT*

15

Bone marrow
ctDNA

X

FFPE

X

Genes

658

Cancer Type

Solid tumors (important hallmarks of cancer)

638 DNA

20 RNA (fusions)

TMB, MSI, HRD

Instrument

NextSeq

TAT*

15

Bone marrow
ctDNA
FFPE

X

Genes
Cancer Type
Instrument
TAT*
Bone marrow
ctDNA
FFPE

Taiwan Lab: Our Comprehensive Oncopanels in collaboration with ACT Genomics

Genes Cancer Type Instrument TAT* Bone marrow ctDNA FFPE

ACTOnco®+ (DNA-based)

440

Solid tumors (important hallmarks of cancer)

TMB

Ion Torrent

10

X

ACTDrug® (DNA-based)

40

Solid tumors (screening of actionable genes)

Ion Torrent

10

X

ACTFusion(RNA-based)

31

Solid tumors (actionable fusion genes)

Ion Torrent

10

X

ACTBRCA® (DNA-based)

2

Solid tumors (gene alterations to evaluate PARP inh)

Ion Torrent

10

X

X

ACTHRD™ (DNA-based)

24

Solid tumors (gene alterations to evaluate PARP inh)

NextSeq 550

10

X

ACTRisk(DNA-based)

32

Identifies genetic alterations related to hereditary cancers

NextSeq 550

10

X

Genes

440

Cancer Type

Solid tumors (important hallmarks of cancer)

TMB

Instrument

Ion Torrent

TAT*

10

Bone marrow
ctDNA
FFPE

X

Genes

40

Cancer Type

Solid tumors (screening of actionable genes)

Instrument

Ion Torrent

TAT*

10

Bone marrow
ctDNA
FFPE

X

Genes

31

Cancer Type

Solid tumors (actionable fusion genes)

Instrument

Ion Torrent

TAT*

10

Bone marrow
ctDNA
FFPE

X

Genes

2

Cancer Type

Solid tumors (gene alterations to evaluate PARP inh)

Instrument

Ion Torrent

TAT*

10

Bone marrow
ctDNA

X

FFPE

X

Genes

24

Cancer Type

Solid tumors (gene alterations to evaluate PARP inh)

Instrument

NextSeq 550

TAT*

10

Bone marrow
ctDNA
FFPE

X

Genes

32

Cancer Type

Identifies genetic alterations related to hereditary cancers

Instrument

NextSeq 550

TAT*

10

Bone marrow
ctDNA

X

FFPE

Reach out to our genomics team and see how we can help advance your research in the field of Solid Tumor NGS.

Cerba US Expansion Tour VF.00_04_27_19.Still010

Reach out to our genomics team and see how we can help advance your research in the field of Solid Tumor NGS

Contact Us