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Processing Peripheral Blood Mononuclear Cells (PBMCs) And Bone Marrow Mononuclear Cells (BMMCs) For Clinical Trials

Our global network of pre processing laboratories ensures we are ideally suited to isolate and either store and analyze PBMC and BMMC samples on a global scale

The usefulness and efficiency of PBMC studies should not be overlooked. The increased use of these immune mononuclear cells as a promising indicator of drug efficacy in clinical trials as well as the increased convenience of working with samples versus conducting testing makes PBMCs crucial. At Cerba Research we embrace the potential of PBMC activities to maximize impact in clinical research.  

To keep up with rising clinical research demand we perform various PBMC activities like isolation from whole blood samples and DNA extraction using advanced technologies and equipment.

  • PBMC isolation on a global scale  
  • Harmonized SOP/QC and instrumentation  
  • Utilize Density Grade Centrifugation (DCG) with CPT® tubes  
  • For use in immunology, infectious disease, hematological malignancies, vaccine development, transplant therapy, personalized medicine, and toxicology. 
  • At Cerba Research, we can also efficiently isolate BMMCs for your clinical trials. We have done so on numerous occasions, mostly for hematological malignancy trials. 

Harmonized SOPs on a global scale for PBMCs isolation, cryopreservation, and storage ensuring high viability and recovery

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Viability ≥97%

Post collection using CPTtubes , the average viability obtained is 99.3% after 4 hrs, 97.9% after 24 hrs, and 96.8% and 85.5% respectively post-thawing

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Recovery ≥75%

After thawing the average recovery is 75%

Premium Logistics

  • Management of sample processing labs
  • PBMC personnel training program and certification
  • Custom sampling kits preparation
  • Sample tracking and tracing (e.g. guaranteeing a temperature-controlled supply chain and online-sample timelines)
  • Premium courier transportation in accordance with ADR & IATA regulations

High Quality Standards

  • All our pre-processing labs are accredited to the relevant local laboratory accreditation standards, which include: CAP, GCP, GLP, ISO17025/15189
  • Quality control and personnel trainings are monitored on-site to ensure compliance with the processing procedures required by the customer

Extensive Network

  • 45+ processing labs in America, Europe, Africa, Asia, and Australia
  • Ability to on-board lab partners worldwide
  • Processing labs in 25+ countries

Standardized SOPs

  • Our standard PBMC processing protocol includes Vacutainer® CPT mononuclear cell preparation tube
  • Customized upon request short turnaround times
  • Same-day PBMC isolation (Turnaround times may vary from one country to another, reflecting possible transportation delays or excessive workloads within the lab.)

A stylised map of the world

Montreal, Canada

Schaijk, The Netherlands

Rijswijk, The Netherlands

Rotterdam, The Netherlands

Durban, South Africa

Genetics/NGS, Flow Cytometry, Histopathology/IHC, Safety testing, mycobacterium tuberculosis lab

Cape Town, South Africa

Genetics/NGS, Flow Cytometry, Histopathology/IHC, Safety testing, mycobacterium tuberculosis lab

Russia 2

Russia 1

Ukraine

Turkey

Israel

Middle East 1

East Africa 6

East Africa 5

East Africa 4

East Africa 3

East Africa 2

East Africa 1

West Africa 4

West Africa 3

West Africa 2

West Africa 1

South Africa 8

South Africa 7

South Africa 6

South Africa 5

South Africa 4

South Africa 3

South Africa 2

The Netherlands

France 2

Costa Rica

Panama

Colombia

Peru

Brazil

Argentina

Chile

India 2

India 1

Australia 2

Singapore 2

Singapore 1

South Korea

China 3

China 2

Japan 2

USA 4

USA 3

Mexico 3

Mexico 2

Mexico 1

USA 2

New York 2

Spain

UK

Rotterdam & Rijswijk, The Netherlands

BSL3, Pre-clinical, Molecular Biology, Genetics/NGS, Pathology, Virology

Ghent

Routine, Molecular Biology, Bioanalytical Lab, Flow Cytometry, Microbiology

Paris, France

Genetics /NGS, Molecular Biology, IVD, Flow Cytometry, Histopathology/IHC, Virology, Microbiology, Preclinical, Biorepository.

Montpellier, France

Genetics /NGS, Molecular Biology, IVD, Flow Cytometry, Histopathology/IHC, Virology, Microbiology, Preclinical, Biorepository.

Johannesburg, South Africa

Routine, Genetics/NGS, Molecular  Biology, Flow Cytometry, Histopathology/IHC, Virology, Microbiology, BSL3, Biorepository

Sydney, Australia

Routine, Molecular Biology, Flow Cytometry, Virology

New York, USA

Routine, Genetics/NGS, Molecular Biology, Flow Cytometry, Bioanalytical Lab/PK, Histopathology/IHC

Tokyo, Japan

Genetics/NGS, Molecular Biology, Flow Cytometry, Histopathology/IHC

Taipei City, Taipei

Routine, Genetics/NGS, Flow Cytometry, Histopathology/IHC Lab/PK

Shanghai, China

Routine, Genetics/NGS, Molecular Biology, Flow Cytometry, Bioanalytical Lab/PK, Histopathology/IHC

Research & Partner labs

Pre-Processing labs

Office locations and Technical Platforms

Reach out to our experts and see how we can help advance your clinical trial