Powering the Next Generation of Infectious Disease Interventions

Evaluating both humoral and cellular immunity is essential for vaccine and therapeutic development. We work with you to define testing strategies that align with your endpoints and provide meaningful insight into immune protection.

Our techniques and approaches include:

• Serology assays (ELISA, MSD) to quantify antigen-binding antibody responses 
• Neutralizing antibody assays to measure functional immune responses 
• ELISpot and FluoroSpot assays to assess antigen-specific T and B cell responses 
• Comprehensive immune phenotyping, utilizing high-parameter spectral flow cytometry to characterize cell populations, including detailed activation and exhaustion profiling
• Functional T-cell profiling to measure antigen-specific cytokine production at the single-cell level using advanced ICS flow cytometry assay (intra-cellular cytokine staining) 
• Multiplex biomarker profiling for pharmacodynamic and safety assessment

Molecular and genomic data provide critical insight into pathogen evolution, host response, and treatment resistance. Our teams deliver high-quality sequencing and molecular analysis to support both exploratory research and clinical endpoints, generating regulatory-ready datasets that complement functional virology and immunology findings.

Our techniques and approaches include:

• Viral and bacterial genome and amplicon sequencing using NGS and long-read technologies to enable variant identification, surveillance, and high-resolution mutation detection (e.g., SARS-CoV-2, RSV, hMPV, Influenza, PIV-3, Dengue virus, CMV, HBV, HCV, HDV, 16S rRNA)
• (RT-)qPCR and (RT-)ddPCR for sensitive detection and quantification of viral, bacterial, and host genetic markers
• T-cell receptor (TCR) and B-cell receptor (BCR) sequencing to assess adaptive immune responses and vaccine-induced immunity
• HLA typing and immunogenetics for patient stratification and safety assessment
• Bioinformatics pipelines delivering structured, traceable, and regulatory-ready molecular datasets

Robust preclinical models help you understand disease mechanisms, transmission, and therapeutic impact before entering the clinic. We develop and apply models that reflect real-world infection and immune conditions.

Our techniques and approaches include:

• Ferret models (including naïve, immunocompromised and pre-immune systems) for respiratory virus research and transmission studies 
• Animal infection models tailored to your target pathogen 
• Immunocompromised models to evaluate prolonged infection and antiviral efficacy 
• Transmission models to study viral spread and intervention impact 
• Well-designed model development
• High-containment BSL-3 facilities supporting safe and compliant preclinical research

Delivering consistent, high-quality data across global infectious disease trials requires careful coordination, robust processes, agile troubleshooting, and full visibility at every step. We manage the operational complexity so you can stay focused on your study objectives and timelines.

Our techniques and approaches include:

• Global sample logistics planning, including temperature-controlled transport and dry-ice shipments 
• Custom clinical trial kit design, production, and distribution, with 135,000+ kits annually
• Pre-labelled kits and standardized lab manuals to ensure protocol adherence across sites 
• PBMC isolation, processing, and cryopreservation through a harmonized global network 
• Biorepository services for secure, compliant sample storage and traceability 
• Customs and documentation support, including customs pre-clearance and validated paperwork to reduce border delays
• Multiple courier options (standard, premium, and in-house) worldwide, selected based on sample risk and timeline criticality
• Seamless integration of central and specialty laboratory testing across regions

Custom assays support targeted scientific questions and regulatory requirements across infectious disease programs. We develop and implement fit-for-purpose assays that generate robust, reproducible data to support exploratory research and clinical endpoints across all study phases.

Our approaches include:

• Development and fit-for-purpose validation of custom molecular, serological, cellular, and tissue-based assays
• Assay implementation in ISO-, CAP-, CLIA-, and GLP/GCLP-compliant laboratory environments to support clinical trials
• Technology transfer and technical qualification, including SOP development, method verification, and operator training
• Multi-site assay harmonization to ensure consistent execution and comparable, regulatory-ready data
• Integration of custom assays with clinical trial operations, including kit design, sample workflows, PBMC processing, and biobanking support