Our Clinical Trial Laboratory Services

With Cerba Research’s clinical trial laboratory services, your samples are in safe hands. We offer comprehensive clinical trial laboratory testing, from safety to specialty, ensuring that you meet your objective.

Our capabilities include: 

• Standard safety testing – standard haematology, biochemistry panels, urinalysis, serology & coagulation testing

• Molecular biology testing – (q)PCR, RT-(q)PCR, dd-PCR, Multiplex PCR, BioFire FilmArray, Seegene panels

• Lab testing in clinical trials – (incl. assay development & technology transfer) – biomarker-driven trial solutions

• Flow cytometry – BD FACS Canto™ II (12-Color), Cytek Aurora (>40 Colors), BD FACS lyric whole blood, bone marrow, PBMC
• Histopathology and anatomic pathology – Multiplex and standard IHC, Immunostaining, ISH/FISH, 200+ biomarkers FFPE, Cryosections Leica, Roche Ventana, RUO/IVD
• Genetics/NGS – NGS (WEG, WGS), mutation analysis, Illumina short read sequencing (MiSeq, HiSeq, NextSeq, NovaSeq), PacBio and Oxford Nanopore Technologies long read sequencing & Sanger, Nanostring

• Cell and Gene Therapy – up to 4th field HLA typing, minimal residual disease testing (MRD), Replication Competent Lentivirus/Retrovirus testing (RCL and RCR), Vector Copy Number testing (VCN), Vector Integration Site analysis (VIS/ISA), Replication competent Adenovirus testing, therapeutic vector copies, shedding studies (PK/PD) and immune repertoire sequencing, TAbs/ADA for therapeutic vectors/proteins, Viral vector sequence integrity by sequencing.

• Microbiology – culture and identification, antibiotic resistance testing, microbiome analysis (sequencing) targeted sequencing, bacterial whole genome sequencing including hybrid assemblies of short and long read sequencing, whole metagenome sequencing

• Cell Isolations – PBMC, BMMC, CD138+ isolations performed in-house, pre-analytical processing network of labs

• ELISA-based Assays – ELISA, MSD S600 Meso Scale Discovery, Luminex, Ella ProteinSimple, Quanterix Simoa HD1

• Bioanalysis – PharmacoKinetics, drug performance with PK, PD/ADA, small & large molecules, ELISA-based methods LC-MS/MS

• Functional cell-based assays – T-cell activation, ADCC, ELISpot

• Virology testing -Virus Culture, TCID50, neutralization assays, inhibition assays, viral load, genotyping & phenotyping, short and long read sequencing, minor variant analyses, antiviral resistance mutations, consensus sequencing, Virome

• Digital imaging – Transforming visual results into quantifiable data with Halo® and Visiopharm® Software

• Bio-informatics solutions – customized pipelines in virology and bacteriology, reference conversion options, tailor made analysis of clinical trial data (e.g., treatment emerging mutations)