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Processing Peripheral Blood Mononuclear Cells (PBMC) for Clinical Trials

Cerba Research and Viroclinics-DDL (a Cerba Research Company), are specialized and central laboratories in clinical trials renowned on functional and analytical tests downstream of PBMCs isolation (Flow Cytometry, ELISA, ELIspot, pSTAT, NGS, Protein Extraction and Quantification, etc.), joined together their capabilities and expertise to guarantee the customers a high level of quality from sample collection to processing, shipping, handling, storage and analysis worldwide.

The usefulness and efficiency of PBMC studies should not be overlooked. The increased use of these immune cells as a promising indicator of drug efficacy in clinical trials as well as the increased convenience of working with samples versus conducting testing makes PBMCs crucial. At Cerba Research we embrace the potential of PBMC activities to maximize impact in clinical research.

To keep up with rising clinical research demand we perform various PBMC activities like isolation from whole blood samples and DNA extraction using advanced technologies and equipment.

  • PBMC isolation on a global scale
  • Harmonized SOP/QC and instrumentation
  • Utilize Density Grade Centrifugation (DCG) with CPT® tubes
  • For use in immunology, infectious disease, hematological malignancies, vaccine development, transplant therapy, personalized medicine, and toxicology.

Harmonized SOPs on a global scale for PBMCs isolation, cryopreservation and storage, ensuring high viability and recovery.

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Viability ≥97%

Post collection using CPTtubes , the average viability obtained is 99,3% after 4 hours and 97,9% after 24hrs and 96,8% and 85,5% respectively post-thawing (source: internal data.)

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Recovery ≥75%

After thawing the average recovery is 75% (source: internal data.)

PBMC Capability & Expertise

Premium Logistics

  • Management of sample processing labs  
  • PBMC personal training program and certification 
  • Custom sampling kits preparation  
  • Sample tracking and tracing (e.g. guaranteeing a temperature-controlled supply chain and online-sample timelines.)  
  • Premium courier transportation in accordance with ADR and IATA regulations 

High Quality Standards

  • All our pre-processing labs are accredited to the relevant local laboratory accreditation standards, which include: CAP, GCP, GLP, ISO17025/15189.  
  • Quality control and personnel training is monitored on-site to ensure compliance with the processing procedures required by the customer. 

Extensive Network

  • 45 processing labs in America, Europe, Africa, Asia, and Australia
  • Ability to on-board lab partners worldwide

Standardized SOP

  • Our standard PBMC processing protocol includes Vacutainer® CPT Mononuclear Cell Preparation Tube
  • Customized upon request short turnaround times
  • Same-day PBMC isolation

Turnaround times may vary from one country to another, reflecting possible transportation delays or excessive workloads within the lab.

North America (New York, San Diego, Richmond) – Central America (Mexico, Costa Rica) – Latin America (Argentina, Chili, Peru, Brazil, Colombia) – Europe (Belgium, Netherlands, UK, Serbia, Turkey, Spain, Ukraine) – Africa (South Africa, Kenya) – Asian Pacific (South Korea, Philippines, Japan, India, Australia, Israel, China)
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