Genomics For Infectious Diseases

At Cerba Research, we offer high-quality processing of samples with superior services, including fast turnaround times for testing results, rapid response to individualized needs, and tailor-made reporting to match your data management requirements. These include laboratory analyses of clinical samples, as well as dedicated data analyses and reporting.

We can provide testing of any type of clinical specimen using commercially available assays or our in-house validated assays.

Our Genomic Services for Infectious Diseases

Our service unit has been structured in a way that allows for efficient handling of both small batches of individual samples and large sets of samples required for clinical trials.

We offer molecular virology, bacteriology, and pathology diagnostic solutions using a broad range of cutting-edge equipment.

Broad bacterial screening can be performed using various singleplex or multiplex real-time PCR-based assays, detecting infectious diseases such as:

● Haemophilus influenza
● Moraxella catarrhalis
● Mycoplasma pneumoniae
● Legionella spec
● Pseudomonas aeruginosa
● Streptococcus pneumoniae
● Staphylococcus aureus
● Streptococcus pyogene

Cerba Research Genomic Capabilities For Infectious Diseases

We are your trusted partner for your Genomic needs in Infectious Diseases

qPCR

ddPCR

Whole Exome Sequencing

Whole Genome Sequencing

Single Cell Sequencing

RNA – sequencing

B-Cell Receptor / T-Cell Receptor Sequencing

Microbiome

The 16S rRNA gene is present in all bacterial genomes and demonstrates considerable sequence diversity among different bacteria, enabling characterization of complex microbial communities at the genus level. Its nine hypervariable regions (I.e., V1 to V9) exhibit variable degrees of sequence diversity among different bacterial genera.

We offer amplification of the V1-V2, V3-V4 or V4 region (depending on the sample type) and sequencing on an Illumina sequencing platform. The generated reads are classified using a the well-known QIIME II pipeline combined with the Silva reference database, resulting in community profiles, alpha diversity (diversity within a sample) and beta diversity (diversity between samples).

Whole Genome Sequencing

Besides microbiome analysis, Cerba Research also offer whole genome sequence analysis of isolated bacterial strains. These whole genome data can be used for epidemiological purposes (e.g., MRSA outbreaks) or to support the clinical development of targeted anti-bacterial therapies.

Genomic DNA of cultured bacterial strains can be sequenced on an Illumina sequencing platform (short reads) or combined with sequencing on an Oxford Nanopore Technology platform (long-reads). Reports can include de novo (short) or hybrid (combined) assembly, phylogenetics and AMR prediction.